How did God deal with the sin of Adam and Eve? First, He confronted them! After eating of the forbidden fruit, they realized that they were naked, and felt ashamed; so they took leaves and made coverings to hide parts of their bodies. Later when God came to the garden, they tried to hide themselves from God. Although God knew what they had done, He gave them an option to explain.
Then we have the first sin of trying to pass the buck: Adam accused Eve, and she accused the serpent. As the result of their disobedience, a curse was put on each. Because of their disobedience man would earn a livelihood by the sweat of his brow; women would suffer intense pain during childbirth, and serpents would crawl on their bellies through dust of the earth.
But what happened to Adam and Eve? They were driven from the garden and a gate to the garden secured so they could not re-enter. But God slew some animals and took pelts and made them clothes. And if I understand correctly, the blood shed was to be a sacrifice for their sin: because without shedding of blood there is no remission of sin. And in the future mankind would be born with sinful natures, and only the blood of Jesus would cover their sins.
“Therefore, the Lord God sent him out of the garden of Eden to till the ground from which he was taken. So He drove out the man; and He placed cherubim at the east of the garden of Eden, and a flaming sword which turned every way, to guard the way to the tree of life.” Genesis 3: 23-24
Heavenly Father, though the first man and woman sinned, and each person since has been born with sinful natures, thanks for providing a way of escape through Your Son Jesus Christ in whose name we pray. Amen.